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RLN2 Antibody

CAT: 0223-60-368Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-368Size:400 µL
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Background
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.
NCBI Gene ID
6019
Swiss Prot
P04090
Accession Number
P04090
Host
Rabbit
Reactivity
Human
Immunogen
This RLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-165 amino acids from the C-terminal region of human RLN2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
21 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RLN2
NCBI Official Name
Prorelaxin H2
NCBI Organism
Homo sapiens
Background Reference 01
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 02
Vogel, I., et al. In Vivo 23 (6) :1005-1009 (2009)
Background Reference 03
Dschietzig, T., et al. Regul. Pept. 155 (1-3), 163-173 (2009) :
Background Reference 04
Mookerjee, I., et al. FASEB J. 23 (4) :1219-1229 (2009)
Other Product Names
Prorelaxin H2, Relaxin B chain, Relaxin A chain, RLN2
Tested Applications
WB
Protein ID
132281
Physical Properties
Liquid

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