RLN2 Antibody

• Background :

  Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.

• NCBI Gene ID :

  6019

• Swiss Prot :

  P04090

• Accession Number :

  P04090

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This RLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-165 amino acids from the C-terminal region of human RLN2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  21 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  RLN2

• NCBI Official Name :

  Prorelaxin H2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Background Reference 02 :

  Vogel, I., et al. In Vivo 23 (6) :1005-1009 (2009)

• Background Reference 03 :

  Dschietzig, T., et al. Regul. Pept. 155 (1-3), 163-173 (2009) :

• Background Reference 04 :

  Mookerjee, I., et al. FASEB J. 23 (4) :1219-1229 (2009)

• Other Product Names :

  Prorelaxin H2, Relaxin B chain, Relaxin A chain, RLN2

• Tested Applications :

  WB

• Protein ID :

  132281

• Physical Properties :

  Liquid