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IQSEC1 Antibody

CAT: 0223-8009-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8009-01Size:0.02 mg
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Background
ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1) . As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis (2,3) . IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy (4) .
NCBI Gene ID
9922
Swiss Prot
Q6DN90
Accession Number
NP_055684
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
IQSEC1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
IQSEC1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IQSEC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
IQSEC1 antibody is human, mouse and rat reactive. At least four isoforms of IQSEC1 are known to exist. IQSEC1 antibody is predicted to not cross-react with IQSEC2.
Symbol
IQSEC1
Positive Control 2
Cat. No. 17-208 - A-20 Cell Slide
NCBI Official Name
IQ motif and Sec7 domain 1
NCBI Organism
Homo sapiens
Background Reference 01
Someya A, Sata M, Takeda K, et al. ARF-GEP (100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. Proc. Natl. Acad. Sci. U.S.A. 2001; 98:2413-8.
Background Reference 02
Dunphy JL, Moravec R, Ly K, et al. The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. Curr. Biol. 2006; 16:315-20.
Background Reference 03
Moravec R, Conger KK, D'Souza R, et al. BRAG2/GEP100/IQSec1 interacts with clathrin and regulates a5B1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5) . J. Biol. Chem. 2012; 287:31138-47.
Background Reference 04
Hu Z, Du J, Yang L, et al. GEP100/Arf6 is required for epidermal growth factor-induced ERK/Rac1 signaling and cell migration in human hepatoma HepG2 cells. PLoS One 2012; 7:e38777.
Other Product Names
IQ motif and Sec7 domain 1, ADP-ribosylation factors guanine nucleotide-exchange protein 100, ARFGEP100, BRAG2, Brefeldin-resistant Arf-GEF 2 protein
Tested Applications
ELISA, WB, ICC, IF
Protein ID
50582989
Physical Properties
Liquid

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