IQSEC2 Antibody

CAT: 0223-8011-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-8011-01Size:0.02 mg
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Background
ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. Similar to the related protein IQSEC1, IQSEC2 is a guanine nucleotide exchange protein for ARF1 and ARF6 that belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1,2) . IQSEC2 is a major component of the postsynaptic density (PSD) and colocalizes with PSD-95. It has been suggested to modulate the functions of the ARF proteins (1) . Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation (3) .
NCBI Gene ID
23096
Swiss Prot
Q5JU85
Accession Number
NP_001104595
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
IQSEC2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Buffer
IQSEC2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IQSEC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
IQSEC2 antibody is human, mouse and rat reactive. At least two isoforms of IQSEC2 are known to exist; this antibody will only detect the larger isoform. IQSEC2 antibody is predicted to not cross-react with IQSEC1.
Symbol
IQSEC2
NCBI Official Name
IQ motif and Sec7 domain 2
NCBI Organism
Homo sapiens
Background Reference 01
Murphy JA, Jensen ON, and Walikonis RS. BRAG1, a SEC7 domain-containing protein, is a component of the postsynaptic density of excitatory synapses. Brain Res. 2006; 1120:35-45.
Background Reference 02
Someya A, Sata M, Takeda K, et al. ARF-GEP (100), a guanine nucleotide-exchange protein for ADP-ribosy
Background Reference 03
Shoubridge C, Tarpey PS, Abidi F, et al. Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual ability. Nat. Genet. 2010; 42:486-8.
Other Product Names
IQ motif and Sec7 domain 2, Brefeldin-resistant Arf-GEF 1 protein, BRAG1, MRX1
Tested Applications
ELISA, WB, IHC-P
Protein ID
162138911
Physical Properties
Liquid

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