Anti-NDST2 Antibody

• Background:

  The N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 (NDST2) protein, also known as N-heparan sulfate sulfotransferase 2, and the highly related protein NDST1 have key roles in the sulfation of heparan sulfate proteoglycans, molecules that are present of cell surfaces and the extracellular matrix (1,2) . NDST1 and NDST2 are dispensable for mesodermal differentiation into osteoblasts but necessary for induction of adipocytes and neural cells (3) .

• Description:

  Boster Bio Anti-NDST2 Antibody (Catalog # A08570) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  NST2, HSST2, N-heparan sulfate sulfotransferase 2, NDST-2

• Gene Name:

  NDST2

• UniProt:

  P52849

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  NDST2 antibody is human, mouse and rat reactive. At least two isoforms of NDST2 are known to exist; this antibody will only detect the larger isoform. NDST2 antibody is predicted not to cross-react with other members of the NDST protein family.

• Immunogen:

  NDST2 antibody was raised against a 16 amino acid peptide near the amino terminus of human NDST2. The immunogen is located within amino acids 20 - 70 of NDST2.

• Clonality:

  Polyclonal

• Applications:

  ELISA, WB, IF

• Field of Research:

  Stem Cells

• Purification:

  NDST2 antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413) .

• Molecular Weight:

  100875 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  NDST2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

• Fragment:

  IgG

• Other Gene Names:

  N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2

• Subcellular Location:

  Golgi apparatus membrane ; Single-pass type II membrane protein .

• Prediction Reactivity:

  Bovine

• Protein Name:

  N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2