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SPINSTER Antibody

CAT: 0223-7651-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7651-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SPINSTER, also known as SPNS1 or SPIN1, is a 528 amino acid multi-pass membrane protein that localizes to the inner mitochondrial membrane and belongs to the spinster subfamily of the major facilitator superfamily (1) . SPINSTER interacts with Bcl-x and Bcl-2 and, via this interaction, is thought to be involved in necrotic or autophagic cell death (2) . The related protein SPNS2 is critical for the normal lymphocyte localization and mammalian immune system function (1,3) .
NCBI Gene ID
83985
Swiss Prot
Q9H2V7
Accession Number
NP_001135920
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
SPINSTER antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (83%), Rat: (81%), Mouse: (81%)
Buffer
SPINSTER antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SPINSTER antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SPINSTER antibody is human specific. At least four isoforms of SPINSTER are known to exist. This antibody is predicted to not cross-react with other members of the spinster family of proteins.
Symbol
SPNS1
Positive Control 2
Cat. No. 1309 - Human Placenta Tissue Lysate
Positive Control 3
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Spinster homolog 1 (Drosophila)
NCBI Organism
Homo sapiens
Background Reference 01
Saier MH Jr, Beatty JT, Goffeau A, et al. The major facilitator superfamily. J. Mol. Microbiol. Biotechnol. 1999; 1:257-79.
Background Reference 02
Yanagisawa H, Miyashita T, Nakano Y, et al. HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. Cell Death Differ. 2003; 10:798-807.
Background Reference 03
Nakano Y, Fujitani K, Kurihara J, et al. Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster. Mol. Cell. Biol. 2001; 21:3775-88.
Other Product Names
SPINSTER Antibody: LAT, nrs, SPIN1, SPINL, HSpin1, PP2030, PP20300, Protein spinster homolog 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
215490098
Physical Properties
Liquid

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