APPBP2 Antibody

• Background :

  The amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (APPBP2), also known as PAT1, interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing (1) . The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease (2) . APPBP2 has been found to be highly expressed in breast cancer (3) .

• NCBI Gene ID :

  10513

• Swiss Prot :

  Q92624

• Accession Number :

  NP_006371

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  APPBP2 antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1303 - Human Brain Tissue Lysate

• Concentration :

  1 mg/mL

• Buffer :

  APPBP2 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  APPBP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment :

  IgG

• Specificity :

  APPBP2 antibody is human, mouse and rat reactive. At least two isoforms of APPBP2 are known to exist; this antibody will detect both isoforms.

• Symbol :

  APPBP2

• Positive Control 2 :

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name :

  Amyloid beta precursor protein (cytoplasmic tail) binding protein 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Zheng P, Eastman J, Vande Pol S, et al. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc. Natl. Acad. Sci. USA 1994; 95:14745-50.

• Background Reference 02 :

  Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 1994; 10:373-403.

• Background Reference 03 :

  Li J, Yang Y, Peng Y, et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat. Genet. 2002; 31:133-4.

• Other Product Names :

  APPBP2 Antibody: PAT1, APP-BP2, HS.84084, KIAA0228, PAT1, Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  18104962

• Physical Properties :

  Liquid