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APPBP2 Antibody

CAT: 0223-7563-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7563-01Size:0.02 mg
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Background
The amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (APPBP2), also known as PAT1, interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing (1) . The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease (2) . APPBP2 has been found to be highly expressed in breast cancer (3) .
NCBI Gene ID
10513
Swiss Prot
Q92624
Accession Number
NP_006371
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
APPBP2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
APPBP2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
APPBP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
APPBP2 antibody is human, mouse and rat reactive. At least two isoforms of APPBP2 are known to exist; this antibody will detect both isoforms.
Symbol
APPBP2
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Amyloid beta precursor protein (cytoplasmic tail) binding protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Zheng P, Eastman J, Vande Pol S, et al. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc. Natl. Acad. Sci. USA 1994; 95:14745-50.
Background Reference 02
Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 1994; 10:373-403.
Background Reference 03
Li J, Yang Y, Peng Y, et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat. Genet. 2002; 31:133-4.
Other Product Names
APPBP2 Antibody: PAT1, APP-BP2, HS.84084, KIAA0228, PAT1, Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
18104962
Physical Properties
Liquid

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