APPBP2 Antibody

• Background:

  The amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (APPBP2), also known as PAT1, interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing (1) . The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease (2) . APPBP2 has been found to be highly expressed in breast cancer (3) .

• NCBI Gene ID:

  10513

• Swiss Prot:

  Q92624

• Accession Number:

  NP_006371

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  APPBP2 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1303 - Human Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  APPBP2 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  APPBP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  APPBP2 antibody is human, mouse and rat reactive. At least two isoforms of APPBP2 are known to exist; this antibody will detect both isoforms.

• Symbol:

  APPBP2

• Positive Control 2:

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name:

  Amyloid beta precursor protein (cytoplasmic tail) binding protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zheng P, Eastman J, Vande Pol S, et al. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc. Natl. Acad. Sci. USA 1994; 95:14745-50.

• Background Reference 02:

  Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 1994; 10:373-403.

• Background Reference 03:

  Li J, Yang Y, Peng Y, et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat. Genet. 2002; 31:133-4.

• Other Product Names:

  APPBP2 Antibody: PAT1, APP-BP2, HS.84084, KIAA0228, PAT1, Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  18104962

• Physical Properties:

  Liquid