APPL2 Antibody

• Background:

  Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.

• NCBI Gene ID:

  55198

• Swiss Prot:

  Q8NEU8

• Accession Number:

  Q8NEU8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This APPL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the N-terminal region of human APPL2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  74 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  APPL2

• NCBI Official Name:

  DCC-interacting protein 13-beta

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chial, H.J., et al. PLoS ONE (8), E12471 (2010) :

• Background Reference 02:

  Rashid, S., et al. J. Biol. Chem. 284 (27) :18115-18128 (2009)

• Background Reference 03:

  Chial, H.J., et al. Traffic 9 (2) :215-229 (2008)

• Background Reference 04:

  Nechamen, C.A., et al. Mol. Cell. Endocrinol. 260-262, 93-99 (2007) :

• Other Product Names:

  DCC-interacting protein 13-beta, Dip13-beta, Adapter protein containing PH domain, PTB domain and leucine zipper motif 2, APPL2, DIP13B

• Tested Applications:

  WB

• Protein ID:

  160419148

• Physical Properties:

  Liquid