TBX21 Antibody

• Background:

  TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box (1,2) . Members of this family include transcription factors involved in the regulation of developmental processes (2) . Studies in mouse and humans show that TBX21 is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (1,3) . Expression of the human ortholog also correlates with interferon-gamma expression in Th1 and natural killer cells, suggesting a TBX21 may play a role in initiating Th1 lineage development from naive Th precursor cells. (3) .

• NCBI Gene ID:

  30009

• Swiss Prot:

  Q9UL17

• Accession Number:

  NP_037483

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  TBX21 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1210 - HEK293 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  TBX21 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TBX21 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  TBX21 antibody is human and mouse reactive.

• Symbol:

  TBX21

• Positive Control 2:

  Cat. No. 17-010 - HEK293 Cell Slide

• NCBI Official Name:

  T-box 21

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100:655-69.

• Background Reference 02:

  Naiche LA, Harrelson Z, Kelly RG, et al. T-box genes in vertebrate development. Annu. Rev. Genet. 2005; 39:219-39.

• Background Reference 03:

  Hibbert L, Pflanz S, De Waal Malefyt R, et al. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J. Interfeon Cytokine Res. 2003; 23:513-22.

• Other Product Names:

  TBX21 Antibody : TBET, T-PET, T-bet, TBLYM, TBET, T-box transcription factor TBX21, T-cell-specific T-box transcription factor T-bet, T-box protein 21

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  7019549

• Physical Properties:

  Liquid