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TBX21 Antibody

CAT: 0223-7477-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7477-01Size:0.02 mg
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Background
TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box (1,2) . Members of this family include transcription factors involved in the regulation of developmental processes (2) . Studies in mouse and humans show that TBX21 is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (1,3) . Expression of the human ortholog also correlates with interferon-gamma expression in Th1 and natural killer cells, suggesting a TBX21 may play a role in initiating Th1 lineage development from naive Th precursor cells. (3) .
NCBI Gene ID
30009
Swiss Prot
Q9UL17
Accession Number
NP_037483
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
TBX21 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
TBX21 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TBX21 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
TBX21 antibody is human and mouse reactive.
Symbol
TBX21
Positive Control 2
Cat. No. 17-010 - HEK293 Cell Slide
NCBI Official Name
T-box 21
NCBI Organism
Homo sapiens
Background Reference 01
Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100:655-69.
Background Reference 02
Naiche LA, Harrelson Z, Kelly RG, et al. T-box genes in vertebrate development. Annu. Rev. Genet. 2005; 39:219-39.
Background Reference 03
Hibbert L, Pflanz S, De Waal Malefyt R, et al. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J. Interfeon Cytokine Res. 2003; 23:513-22.
Other Product Names
TBX21 Antibody : TBET, T-PET, T-bet, TBLYM, TBET, T-box transcription factor TBX21, T-cell-specific T-box transcription factor T-bet, T-box protein 21
Tested Applications
ELISA, WB, IF
Protein ID
7019549
Physical Properties
Liquid

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