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TBX1 Antibody

CAT: 0223-63-920Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-920Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS) /velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
NCBI Gene ID
6899
Swiss Prot
O43435
Accession Number
O43435
Host
Rabbit
Reactivity
Human
Immunogen
This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 327-356 amino acids from the C-terminal region of human TBX1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Symbol
TBX1
NCBI Official Name
T-box transcription factor TBX1
NCBI Organism
Homo sapiens
Background Reference 01
Fernando, R.I., et al. J. Clin. Invest. 120 (2) :533-544 (2010)
Background Reference 02
Heike, C.L., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (1) :54-63 (2010)
Background Reference 03
Beaujard, M.P., et al. EurMed Genet 52 (5) :321-327 (2009)
Background Reference 04
Shalaby, A.A., et al. Mod. Pathol. 22 (8) :996-1005 (2009)
Other Product Names
T-box transcription factor TBX1, T-box protein 1, Testis-specific T-box protein, TBX1
Tested Applications
WB, IHC-P, IF
Physical Properties
Liquid

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