APO-E Antibody

• Background:

  APO-E Antibody: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E (APO-E), a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in APO-E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

• NCBI Gene ID:

  348

• Swiss Prot:

  P02649

• Accession Number:

  NP_000032

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  APO-E Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1303 - Human Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig: (78%)

• Buffer:

  APO-E Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  APO-E antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Symbol:

  APOE

• Positive Control 2:

  Cat. No. 10-201 - Human Liver Tissue Slide

• NCBI Official Name:

  Apolipoprotein E

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vasquez EC, Peotta VA, Gava TMC, et al. Cardiac and vascular phenotypes in the epolipoprotein E-deficient mouse. J. Biomed. Sci. 2012; 19:22.

• Background Reference 02:

  Feussner G, Funke H, Weng W, et al. Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and epsilon 1/'null' genotype. Eur. J. Clin. Invest. 1992; 22:599-608.

• Other Product Names:

  APO-E Antibody: AD2, LPG, LDLCQ5, Apolipoprotein E, Apo-E

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  4557325

• Physical Properties:

  Liquid