APO-E Antibody

CAT: 0223-7333-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7333-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
APO-E Antibody: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E (APO-E), a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in APO-E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
NCBI Gene ID
348
Swiss Prot
P02649
Accession Number
NP_000032
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
APO-E Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (78%)
Buffer
APO-E Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
APO-E antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Symbol
APOE
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Apolipoprotein E
NCBI Organism
Homo sapiens
Background Reference 01
Vasquez EC, Peotta VA, Gava TMC, et al. Cardiac and vascular phenotypes in the epolipoprotein E-deficient mouse. J. Biomed. Sci. 2012; 19:22.
Background Reference 02
Feussner G, Funke H, Weng W, et al. Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and epsilon 1/'null' genotype. Eur. J. Clin. Invest. 1992; 22:599-608.
Other Product Names
APO-E Antibody: AD2, LPG, LDLCQ5, Apolipoprotein E, Apo-E
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4557325
Physical Properties
Liquid

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