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Anti-APO-E Antibody

CAT: 0519-A00015-1Size: 0.1 mgDry Ice: NoHazardous: No
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Background
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E (APO-E), a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Defects in APO-E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Description
Boster Bio Anti-APO-E Antibody (Catalog # A00015-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
AD2, LPG, LDLCQ5, Apolipoprotein E, Apo-E
Gene Name
APOE
UniProt
P02649
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
APO-E antibody was raised against a 19 amino acid peptide near the carboxy terminus of human APO-E. The immunogen is located within amino acids 220 - 270 of APO-E.
Clonality
Polyclonal
Tissue Specificity
Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL) . APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Neuroscience
Purification
APO-E Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Molecular Weight
36154 MW
Shipping Conditions
Available
Storage Conditions
APO-E antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Fragment
IgG
Other Gene Names
Apolipoprotein E
Subcellular Location
Secreted
Prediction Reactivity
Pig
Protein Name
Apolipoprotein E

UniProtKB · P02649

Apolipoprotein E

APOE_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02649
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APOE
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Apo-E
EC number
—
Processing
Precursor
Secondary accessions
B2RC15, C0JYY5, Q9P2S4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Disease

Alzheimer diseaseAmyloidosisDisease variantHyperlipidemiaNeurodegeneration

Biological process

Cholesterol metabolismHost-virus interactionLipid metabolismLipid transportSteroid metabolismSterol metabolismTransport

Cellular component

ChylomicronEndosomeExtracellular matrixHDLSecretedVLDL

PTM

GlycationGlycoproteinOxidationPhosphoprotein

Molecular function

Heparin-binding

Ligand

Lipid-binding

Domain

RepeatSignal

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