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CARM1 Antibody

CAT: 0223-7219-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7219-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CARM1 Antibody: Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation. CARM1 functions as a transcriptional co-activator for various nuclear receptors and NF-κ B. It has also been shown to methylate histone H3 arginines, inhibiting the binding of corepressors and protecting chromatin from deacetylation, thereby facilitating transcription.
NCBI Gene ID
10498
Swiss Prot
Q86X55
Accession Number
NP_954592
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
CARM1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/mL
Buffer
CARM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CARM1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 67 kDa
Fragment
IgG
Symbol
CARM1
Positive Control 2
Cat. No. 17-005 - Jurkat Cell Slide
NCBI Official Name
Coactivator-associated arginine methyltransferase 1
NCBI Organism
Homo sapiens
Background Reference 01
Frankel A, Yadav N, Lee J, et al. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J. Biol. Chem. 2002; 277:3537-43.
Background Reference 02
Wolf SS. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans. Cell Mol. Life Sci. 2009; 66:2109-21.
Background Reference 03
Lee DY, Teyssier C, Strahl BD, et al. Role of protein methylation in regulation of transcription. Endocr. Rev. 2005; 26:147-70.
Background Reference 04
Covic M, Hassa PO, Saccani S, et al. Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB dependent gene expression. EMBO J. 2005; 24:85-96.
Other Product Names
CARM1 Antibody: PRMT4, PRMT4, Histone-arginine methyltransferase CARM1, Coactivator-associated arginine methyltransferase 1
Tested Applications
ELISA, WB, IF
Protein ID
40288288
Physical Properties
Liquid

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