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PDGF-B Antibody

CAT: 0223-7199-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7199-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PDGF-B Antibody: The platelet-derived growth factor beta (PDGF-B) is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB) . Mutations in this gene are associated with meningioma , and reciprocal translocations between chromosomes 22 and 7, at sites where the PDGF-B gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans.
NCBI Gene ID
5155
Swiss Prot
P01127
Accession Number
NP_002599
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
PDGF-B Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1464 - Rat Liver Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Sheep: (100%)
Buffer
PDGF-B Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PDGF-B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 27 kDa
Fragment
IgG
Symbol
PDGFB
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Platelet-derived growth factor beta polypeptid
NCBI Organism
Homo sapiens
Background Reference 01
Johnsson A, Heldin CH, Wasteson A, et al. The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J. 1984; 3:921-8.
Background Reference 02
Fredriksson L, Li H, and Eriksson U. The PDGF family: four gene products for five dimeric isoforms. Cyto. Growth Factor Rev. 2004; 15:197-204.
Background Reference 03
Maxwell M, Galanopoulos T, Hedley-Whyte ET, et al. Human meningiomas co-express platelet-derived growth factor) PDGF) and PDGF-receptor genes and their protein products. Int. J. Cancer 1990; 46:16-21.
Background Reference 04
Simon MP, Navarro M, Roux D, et al. Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t (17;22) (q22; q13.1) in Dermatofibrosarcoma protuberans (DP) . Oncogene 2001; 20:2965-75.
Other Product Names
PDGF-B Antibody: SIS, SSV, IBGC5, PDGF2, c-sis, PDGF-2, SIS, Platelet-derived growth factor subunit B, PDGF subunit B
Tested Applications
ELISA, WB, IF
Protein ID
4505681
Physical Properties
Liquid

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