PDGF-B Recombinant Protein

• Background:

  PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C) which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.

• NCBI Gene ID:

  5155

• Swiss Prot:

  P01127

• Accession Number:

  AAH29822

• Tag:

  His Tag & Avi Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Chemokines & Cytokines, Growth Factors

• Buffer:

  0.085% TFA in 30% ACN

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  15 kDa

• Applications Notes:

  This recombinant protein can be used for E, WB. For research use only.

• NCBI Official Name:

  Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hoch RV, Soriano P. 2003, Development 130 (20) : 4769–4784.

• Background Reference 02:

  Olofsson B, et al. 1996, Proc Natl Acad Sci U S A.,93 (6) :2576-81.

• Background Reference 03:

  Joukov V, et al. 1996, EMBO J. 15 (2) : 290–298.

• Background Reference 04:

  Lei KJ, et al. 1993, Oncogene 8 (4) : 925–931.

• Other Product Names:

  PDGFBB, PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3