PDGF Receptor beta (Ab 751) Antibody

• Background:

  PDGF Receptor β encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

• NCBI Gene ID:

  5159

• Swiss Prot:

  P09619

• Accession Number:

  NP_002600.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  PDGF Receptor beta (Ab-751) antibody was raised against a peptide sequence around aa.749~753 (V-D-Y-V-P) derived from Human PDGFRb.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  190 kDa

• Specificity:

  This antibody detects endogenous level of total PDGF Receptor β protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  PDGFRB

• NCBI Official Name:

  Platelet-derived growth factor receptor, beta polypeptide

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lederle W, et al. (2006) Am J Pathol ; 169 (5) : 1767-1783. Vignais ML, et al. (1999) Mol Cell Biol; 19 (5) : 3727-3735. Herrlich A, et al. (1998) Proc Natl Acad Sci U S A; 95 (15) : 8985-8990. Heuchel R, et al. (1999) Proc Natl Acad Sci U S A; 96 (20) : 11410-11415.

• Other Product Names:

  IMF1, IBGC4, JTK12, PDGFR, CD140B, PDGFR1, PDGFR-1

• Tested Applications:

  WB

• Protein ID:

  4505683

• Physical Properties:

  Liquid