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SELK Antibody

CAT: 0223-6975-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6975-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SELK Antibody: SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited
NCBI Gene ID
58515
Swiss Prot
Q9Y6D0
Accession Number
NP_067060
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
SELK Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Pig: (100%)
Buffer
SELK Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SELK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
10 kDa
Fragment
IgG
Symbol
SELK
Positive Control 2
Cat. No. 10-501 - Human Heart Tissue Slide
NCBI Official Name
Selenoprotein K
NCBI Organism
Homo sapiens
Background Reference 01
Lu C, Qiu F, Zhou H, et al. Identification and characterization of selenoprotein K: An antioxidant in cardiomyocytes. FEBS Lett. 2006; 580:5189-97
Background Reference 02
Shchedrina VA, Everly RA, Zhang Y, et al. Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic homeostasis. J. Biol. Chem. 2011; 286:42937-48.
Background Reference 03
Huang Z, Hoffmann FW, Norton RL, et al. Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages. J. Biol. Chem. 2011; 286:34830-8.
Other Product Names
SELK Antibody: SelK, HSPC030, HSPC297, Selenoprotein K, SelK
Tested Applications
ELISA, WB, IF
Protein ID
25014099
Physical Properties
Liquid

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