SELE Antibody

• Background:

  The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.

• NCBI Gene ID:

  6401

• Swiss Prot:

  P16581

• Accession Number:

  P16581

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TRAIL antibody is generated from rabbits immunized with a recombinant protein from the human TRAIL.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  67 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SELE

• NCBI Official Name:

  E-selectin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Palmer, C.N., et al. Diabetes 59 (11) :2945-2948 (2010)

• Background Reference 02:

  Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

• Background Reference 03:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 04:

  Wayman, A.M., et al. Biophys. J. 99 (4) :1166-1174 (2010)

• Other Product Names:

  E-selectin, CD62 antigen-like family member E, Endothelial leukocyte adhesion molecule 1, ELAM-1, Leukocyte-endothelial cell adhesion molecule 2, LECAM2, CD62E, SELE, ELAM1

• Tested Applications:

  WB

• Protein ID:

  126180

• Physical Properties:

  Liquid