ABCA7 Antibody

• Background:

  ABCA7 Antibody: ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.

• NCBI Gene ID:

  10347

• Swiss Prot:

  Q8IZY2

• Accession Number:

  NP_061985

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  ABCA7 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1210 - HEK293 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  ABCA7 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ABCA7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  ABCA7 antibody is predicted to not cross-react with other ABC1 subfamily proteins.

• Symbol:

  ABCA7

• Positive Control 2:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• Positive Control 3:

  Cat. No. 17-010 - HEK293 Cell Slide

• NCBI Official Name:

  ATP-binding cassette, sub-family A (ABC1), member 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kaminski WE, Orsó E, Diederich W, et al. Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7) . Biochem. Biophys. Res. Commun. 2000; 273:532-8.

• Background Reference 02:

  Abe-Dohmae S, Ueda K, and Yokoyama S. ABCA7, a molecule with unknown function. FEBS Lett. 2006; 580:1178-82

• Background Reference 03:

  Ikeda Y, Abe-Dohmae S, Munehira Y, et al. 2003. Post-transcriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. Biochem. Biophys. Res.Commun. 311:313-8.

• Background Reference 04:

  Iwamoto N, Abe-Dohmae S, Sato R, et al. ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J. Lipid Res. 2006; 47:1915-27.

• Other Product Names:

  ABCA7 Antibody: ABCX, ABCA-SSN, ATP-binding cassette sub-family A member 7

• Tested Applications:

  ELISA, WB, IHC-P, ICC, IF

• Protein ID:

  150417984

• Physical Properties:

  Liquid