ABCA7 Antibody

CAT: 0223-6889-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6889-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ABCA7 Antibody: ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
NCBI Gene ID
10347
Swiss Prot
Q8IZY2
Accession Number
NP_061985
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
ABCA7 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
ABCA7 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ABCA7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
ABCA7 antibody is predicted to not cross-react with other ABC1 subfamily proteins.
Symbol
ABCA7
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
Positive Control 3
Cat. No. 17-010 - HEK293 Cell Slide
NCBI Official Name
ATP-binding cassette, sub-family A (ABC1), member 7
NCBI Organism
Homo sapiens
Background Reference 01
Kaminski WE, Orsó E, Diederich W, et al. Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7) . Biochem. Biophys. Res. Commun. 2000; 273:532-8.
Background Reference 02
Abe-Dohmae S, Ueda K, and Yokoyama S. ABCA7, a molecule with unknown function. FEBS Lett. 2006; 580:1178-82
Background Reference 03
Ikeda Y, Abe-Dohmae S, Munehira Y, et al. 2003. Post-transcriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. Biochem. Biophys. Res.Commun. 311:313-8.
Background Reference 04
Iwamoto N, Abe-Dohmae S, Sato R, et al. ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J. Lipid Res. 2006; 47:1915-27.
Other Product Names
ABCA7 Antibody: ABCX, ABCA-SSN, ATP-binding cassette sub-family A member 7
Tested Applications
ELISA, WB, IHC-P, ICC, IF
Protein ID
150417984
Physical Properties
Liquid

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