ABCB7 Antibody

• Background:

  The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X) (q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

• NCBI Gene ID:

  22

• Swiss Prot:

  O75027

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 503-753 of human ABCB7 (NP_004290.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  A-431

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 83kDa

• Fragment:

  IgG

• Symbol:

  ABCB7

• Positive Control 2:

  293T

• Positive Control 3:

  Mouse heart

• NCBI Official Name:

  ATP-binding cassette, sub-family B (MDR/TAP), member 7

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  ABCB7, ABC transporter 7 protein, ABC7, Atm1p, ATP-binding cassette 7, ASAT, EST140535

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid