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ABCB7 Antibody

CAT: 0223-62-131Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-131Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
NCBI Gene ID
22
Swiss Prot
O75027
Accession Number
O75027
Host
Rabbit
Reactivity
Human
Immunogen
This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-746 amino acids from the C-terminal region of human ABCB7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
83 kDa
Fragment
Rabbit Ig
Symbol
ABCB7
NCBI Official Name
ATP-binding cassette sub-family B member 7, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Allikmets, R., et al., Hum. Mol. Genet. 8 (5) :743-749 (1999) .
Background Reference 02
Csere, P., et al., FEBS Lett. 441 (2) :266-270 (1998) .
Background Reference 03
Mao, M., et al., Proc. Natl. Acad. Sci. U.S.A. 95 (14) :8175-8180 (1998) .
Background Reference 04
Shimada, Y., et al., J. Hum. Genet. 43 (2) :115-122 (1998) .
Other Product Names
ATP-binding cassette sub-family B member 7, mitochondrial, ATP-binding cassette transporter 7, ABC transporter 7 protein, ABCB7, ABC7
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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