ABCB7 Antibody

• Background:

  The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.

• NCBI Gene ID:

  22

• Swiss Prot:

  O75027

• Accession Number:

  O75027

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-746 amino acids from the C-terminal region of human ABCB7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  83 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ABCB7

• NCBI Official Name:

  ATP-binding cassette sub-family B member 7, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Allikmets, R., et al., Hum. Mol. Genet. 8 (5) :743-749 (1999) .

• Background Reference 02:

  Csere, P., et al., FEBS Lett. 441 (2) :266-270 (1998) .

• Background Reference 03:

  Mao, M., et al., Proc. Natl. Acad. Sci. U.S.A. 95 (14) :8175-8180 (1998) .

• Background Reference 04:

  Shimada, Y., et al., J. Hum. Genet. 43 (2) :115-122 (1998) .

• Other Product Names:

  ATP-binding cassette sub-family B member 7, mitochondrial, ATP-binding cassette transporter 7, ABC transporter 7 protein, ABCB7, ABC7

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid