ABCA4 Antibody

• Background :

  The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

• NCBI Gene ID :

  24

• Swiss Prot :

  P78363

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 110-300 of human ABCA4 (NP_000341.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  Affinity purification

• Positive Control :

  U-251MG

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 256kDa

• Fragment :

  IgG

• Symbol :

  ABCA4

• Positive Control 2 :

  BT-474

• Positive Control 3 :

  293T

• Positive Control 4 :

  Mouse heart

• Positive Control 5 :

  Mouse lung

• Positive Control 6 :

  Rat eye

• NCBI Official Name :

  ATP-binding cassette, sub-family A (ABC1), member 4

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  ABCA4, ATP-binding cassette, sub-family A (ABC1), member 4, ABC10, ABCR, ARMD2, CORD3, DKFZp781N1972, FFM, RMP, RP19, STGD, STGD1, ATP binding cassette transporter, sub-family A member 4, ATP-binding transporter, retina-specific, ret

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid