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LZTS2 Antibody

CAT: 0223-6635-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6635-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LZTS2 Antibody: The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.
NCBI Gene ID
84445
Swiss Prot
Q9BRK4
Accession Number
NP_115805
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
LZTS2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (95%), Bovine: (95%)
Buffer
LZTS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LZTS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
LZTS2 antibody is predicted to not cross-react with other LZTS family members
Symbol
LZTS2
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
Leucine zipper, putative tumor suppressor 2
NCBI Organism
Homo sapiens
Background Reference 01
Thyssen G, Li TH, Lehmann L, et al. LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin. Mol. Cell. Biol. 2006; 26:8857-67
Background Reference 02
Sudo H and Maru Y. LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing. Hum. Mol. Genet. 2008; 17:2524-40.
Background Reference 03
Sudo H and Maru Y. LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 Katanin. FASEB J. 2007; 21:2086-100.
Background Reference 04
Cabeza-Arvelaiz Y, Thompson TC, Sepulveda JL, et al. LAPSER1: a novel candidate tumor suppressor gene from 10q24.3. Oncogene 2001; 20:6707-17.
Other Product Names
LZTS2 Antibody: LAPSER1, KIAA1813, LAPSER1, Leucine zipper putative tumor suppressor 2, Protein LAPSER1, hLZTS2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
45331215
Physical Properties
Liquid

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