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LZTS1 Antibody

CAT: 0223-56-831Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-831Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.
NCBI Gene ID
11178
Swiss Prot
Q9Y250
Accession Number
Q9Y250
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This LZTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the N-terminal region of human LZTS1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
67 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
LZTS1
NCBI Official Name
Leucine zipper putative tumor suppressor 1
NCBI Organism
Homo sapiens
Background Reference 01
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Background Reference 02
Chattopadhyay, I., et al. Mutat. Res. 696 (2) :130-138 (2010)
Background Reference 03
Califano, D., et al. J. Cell. Physiol. 222 (2) :382-386 (2010)
Background Reference 04
Shyn, S.I., et al. Mol. Psychiatry (2009) In press :
Other Product Names
Leucine zipper putative tumor suppressor 1, F37/esophageal cancer-related gene-coding leucine-zipper motif, Fez1, LZTS1, FEZ1
Tested Applications
WB
Protein ID
46396556
Physical Properties
Liquid

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