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LZTR2 Antibody

CAT: 0223-5623-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5623-01Size:0.02 mg
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Background
LZTR2 Antibody: LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.
NCBI Gene ID
89866
Swiss Prot
Q96JE7
Accession Number
NP_149118
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
LZTR2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Rabbit: (94%)
Buffer
LZTR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LZTR2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
SEC16B
NCBI Official Name
SEC16 homolog B (S. cerevisiae)
NCBI Organism
Homo sapiens
Background Reference 01
Misawa H and Yamaguchi M. Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver. Int. J. Mol. Med.2001; 8:513-20.
Background Reference 02
Yamaguchi M. Novel protein RGPR-p117: its role as the regucalcin gene transcription factor. Mol. Cell. Biochem.2009; 327:53-63.
Background Reference 03
Hotta K, Nakamura M, Nakamura T, et al. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J. Hum. Genet.2009; 54:727-31.
Other Product Names
LZTR2 Antibody: RGPR, LZTR2, SEC16S, PGPR-p117, KIAA1928, RGPR, Protein transport protein Sec16B, Leucine zipper transcription regulator 2, RGPR-p117
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
116235480
Physical Properties
Liquid

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