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AP3M1 Antibody

CAT: 0223-6393-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6393-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
AP3M1 Antibody: The AP3 complex is a heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2) . The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. AP3M1 is highly homologous to AP3M2 but is the preferred binding partner to the YQRL motif from the cytosolic domain of TGN38. AP3M1 has also been shown to interact with the HIV-1 virulence protein Nef.
NCBI Gene ID
26985
Swiss Prot
Q9Y2T2
Accession Number
NP_036227
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
AP3M1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (100%), Bovine: (100%)
Buffer
AP3M1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
AP3M1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
AP3M1 antibody may cross-react with AP3M2.
Symbol
AP3M1
NCBI Official Name
Adaptor-related protein complex 3, mu 1 subunit
NCBI Organism
Homo sapiens
Background Reference 01
Dell'Angelica EC, Ohno H, Ooi CE, et al. AP-3: an adaptor-like protein complex with ubiquitous expression. EMBO J. 1997; 16:917-28
Background Reference 02
Stephens DJ and Banting G. Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120. Biochem. J. 1998; 335:567-72
Background Reference 03
Coleman SH, Van Damme N, Day JR, et al. Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. J. Virol. 2005; 79:2066-78.
Other Product Names
AP3M1 Antibody: AP-3 complex subunit mu-1, AP-3 adapter complex mu3A subunit
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
46370095
Physical Properties
Liquid

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