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NUMB Antibody

CAT: 0223-6311-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6311-01Size:0.02 mg
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Background
NUMB Antibody: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.
NCBI Gene ID
8650
Swiss Prot
P49757
Accession Number
NP_1005743
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
NUMB Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1402 - Mouse Lung Tissue Lysate
Concentration
1 mg/mL
Buffer
NUMB Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NUMB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least four isoforms of NUMB are known to exist; this antibody will detect all of them.
Symbol
NUMB
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Numb homolog (Drosophila)
NCBI Organism
Homo sapiens
Background Reference 01
Zhong W, Feder JN, Jiang MM, et al. Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron 1996; 17:43-53.
Background Reference 02
Wu M, Kwon HY, Rattis F, et al. Imaging hematopoietic precursor division in real time. Cell. Stem Cell 2007; 1:541-54.
Background Reference 03
Conboy IM and Rando TA. The regulation of Notch signaling controls satellite cell activation, cell fate determination in postnatal myogenesis. Dev. Cell 2002; 3:397-409
Background Reference 04
Yogosawa S, Miyauchi Y, Honda R, et al. Mammalian Numb is a target protein of Mdm2, ubiquitin ligase. Biochem. Biophys. Res. Commun. 2003; 302:869-72.
Other Product Names
NUMB Antibody: S171, C14orf41, c14_5527, Protein numb homolog, Protein S171, h-Numb
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
54144625
Physical Properties
Liquid

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