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NUMBL Antibody

CAT: 0223-57-465Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-465Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NUMBL plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
NCBI Gene ID
9253
Swiss Prot
Q9Y6R0
Accession Number
Q9Y6R0
Host
Rabbit
Reactivity
Human
Immunogen
This NUMBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 572-600 amino acids from the C-terminal region of human NUMBL.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Symbol
NUMBL
NCBI Official Name
Numb-like protein
NCBI Organism
Homo sapiens
Background Reference 01
Zhou, L., et al. Biochem. Biophys. Res. Commun. 392 (3) :409-414 (2010)
Background Reference 02
Blom, T., et al. Cancer Genet. Cytogenet. 186 (2) :103-109 (2008)
Background Reference 03
Ma, Q., et al. Cell. Signal. 20 (6) :1044-1051 (2008)
Background Reference 04
Passos Gregorio, S., et al. Schizophr. Res. 88 (1-3), 275-282 (2006) :
Other Product Names
Numb-like protein, Numb-related protein, Numb-R, NUMBL
Tested Applications
WB, IHC-P
Protein ID
14194976
Physical Properties
Liquid

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