PRR5 Antibody

• Background :

  PRR5 Antibody: Proline-rich protein 5 (PRR5), also known as Protor-1, is a 388 amino acid protein in Protor family, is thought to act as a tumor suppressor in breast and colorectal tumorigenesis. PRR5 is widely expressed and possesses two RICTOR interaction sites and a C-terminal Proline rich region. It promotes Rapamycin complex 2 (mTORC2) activity. There are four isoforms of PRR5 that are produced as a result of alternative splicing events and these isoforms play an important role in the modulation of platelet-derived growth factor signaling and in the regulation of PDGFR-beta expression.

• NCBI Gene ID :

  55615

• Swiss Prot :

  P85299

• Accession Number :

  NP_851850

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle

• Purification :

  PRR5 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1220 - SK-N-SH Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  PRR5 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  PRR5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  PRR5 antibody is predicted to not cross-react with other Protor protein family members.

• Symbol :

  PRR5

• NCBI Official Name :

  Proline rich 5 (renal)

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Johnstone CN, Castellvi-Bel S, Chang LM, et al. PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas. Genomics 2005; 85:338-51.

• Background Reference 02 :

  Pearce LR, Huang X, Boudeau J, et al. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem. J. 2007; 405:513-22.

• Background Reference 03 :

  Woo SY, Kim DH, Jun CB, et al. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor expression and signaling. J. Biol. Chem. 2007; 282:25604-12.

• Other Product Names :

  PRR5 Antibody: PP610, PROTOR1, PROTOR-1, FLJ20185k, PP610, Proline-rich protein 5, Protein observed with Rictor-1, Protor-1

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  31317218

• Physical Properties :

  Liquid