RABEX5 Antibody

• Background:

  RABEX5 Antibody: RABEX5 is a guanine nucleotide exchange factor (GEF) that forms a complex with rabaptin-5 and specifically activates Rab5, a small GTPase that plays an essential role in endocytic traffic. RABEX-5 is thought to also interact with another member of the Rab family, Rab22, which targets RABEX5 to early endosomes, allowing it to activate Rab5 and thereby promote Rab5-mediated endosome fusion.

• NCBI Gene ID:

  27342

• Swiss Prot:

  Q9UJ41

• Accession Number:

  NP_055319

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  RABEX5 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1304 - Human Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (100%)

• Buffer:

  RABEX5 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  RABEX5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  At least four isoforms of RABEX5 are known to exist; this antibody will recognize all four. RABEX5 antibody is predicted to not cross-react with other LRRFIP family members.

• Symbol:

  RABGEF1

• NCBI Official Name:

  RAB guanine nucleotide exchange factor (GEF) 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Horiuchi H, Lippe R, McBride HM, et al. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 1997; 90:1149-59.

• Background Reference 02:

  Zhu H, Liang Z, and Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol. Biol. Cell 2009; 20:4720-9.

• Other Product Names:

  RABEX5 Antibody: RAP1, RABEX5, rabex-5, RAP1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  7657496

• Physical Properties:

  Liquid