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Disp2 Antibody

CAT: 0223-4883-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4883-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Disp2 Antibody: Disp2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the Disp proteins have been implicated in these pathways. Recently, it has been shown that Disp2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased Disp2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by Disp2 mutants. At least two isoforms of Disp2 are known to exist. This Disp2 antibody is predicted to not cross-react with Disp1 or Disp3.
NCBI Gene ID
85455
Swiss Prot
A7MBM2
Accession Number
A7MBM2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Disp2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
Disp2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Disp2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
DISP2
NCBI Official Name
Dispatched homolog 2 (Drosophila)
NCBI Organism
Homo sapiens
Background Reference 01
Katoh Y and Katoh M. Identification and characterization of DISP3 gene in silico. Int. J. Oncol.2005; 26:551-6.
Background Reference 02
Katoh Y and Katoh M. Hedgehog signaling pathway and gastric cancer. Can. Biol. & Ther.2005; 4:1050-4.
Background Reference 03
Li N, Flynt AS, Kim HR, et al. Dispatched homolog 2 is targeted by miR-214 through a combination of three week microRNA recognition sites. Nuc. Acids Res.2008; 36:4277-85.
Other Product Names
Disp2 Antibody: DISPB, HsT16908, DISPB, KIAA1742, Protein dispatched homolog 2
Tested Applications
ELISA, WB
Protein ID
160380692
Physical Properties
Liquid

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