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DISP1 Antibody

CAT: 0223-6629-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6629-01Size:0.02 mg
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Background
DISP1 Antibody: DISP1 is the mammalian homolog of the Drosophila Dispatched segment-polarity gene and a key regulator of the Hedgehog (Hh) signaling pathway during embryonic development. DISP1 is required to move Shh from site of synthesis during embryogenesis; mutations in the gene result in lethality at mid-gestation and prevents specification of ventral cell types in the neural tube. Recent results have shown that DISP1 mediates the basolateral secretion of Shh and regulates growth of mammalian long bones through the control of Ihh.
NCBI Gene ID
84976
Swiss Prot
Q96F81
Accession Number
NP_116279
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
DISP1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1212 - 3T3 Cell Lysate
Concentration
1 mg/mL
Buffer
DISP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DISP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of DISP1 are known to exist; this antibody will detect both isoforms. DISP1 antibody is predicted to not cross-react with EMX1.
Symbol
DISP1
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
Dispatched homolog 1
NCBI Organism
Homo sapiens
Background Reference 01
Caspary T, Garcia-Garcia MJ, Huangfu D, et al. Mouse dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling. Curr. Biol. 2002; 12:1628-32
Background Reference 02
Etheridge LA, Crawford TQ, Zhang S, et al. Evidence for a role of vertebrate Disp1 in long-range Shh signaling. Development 2010; 137:133-40.
Background Reference 03
Tsiairis CD and McMahon AP. Disp1 regulates growth of mammalian long bones through the control of Ihh distribution. Dev. Biol. 2008; 317:480-5.
Other Product Names
DISP1 Antibody: DISPA, DISPA, Protein dispatched homolog 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
25952134
Physical Properties
Liquid

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