VPS53 Antibody

CAT: 0223-4595-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4595-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
VPS53 Antibody: The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
NCBI Gene ID
55275
Swiss Prot
Q5VIR6
Accession Number
EAW90658
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
VPS53 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (78%)
Buffer
VPS53 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
VPS53 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
VPS53
NCBI Official Name
Vacuolar protein sorting 53 homolog (S. cerevisiae)
NCBI Organism
Homo sapiens
Background Reference 01
Pfeffer SR. Targeting of proteins to the lysosome. Curr. Top. Microbiol. Immunol.1991; 170:43-65.
Background Reference 02
Liewen H, Meinhold-Heerlein I, Oliveira V, et al. Characterization of the human GARP (Golgi associated retrograde protein) complex. Exp. Cell Res.2005; 306:22-34.
Background Reference 03
Perez-Victoria FJ, Mardones GA, and Bonifacino JS. Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes. Mol. Biol. Cell2008; 19:2350-62.
Background Reference 04
Brass AL, Dykxhoorn DM, Benita Y, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science2008; 319:921-6.
Other Product Names
VPS53 Antibody: HCCS1, hVps53L, pp13624, Vacuolar protein sorting-associated protein 53 homolog
Tested Applications
ELISA, WB
Protein ID
119611064
Physical Properties
Liquid

Related Products

CatalogName
4595PVPS53 Peptide
4593PVPS53 Peptide
56-744VPS54 Antibody
55-511VPS52 Antibody
46-584VPS35 Antibody
22-714VPS35 Antibody
46-584PVPS35 Peptide
64-160WAS Antibody
13-349WAS Antibody
60-596WAS Antibody

Alternative Products

CatalogName
MBS9522993-01VPS53 Antibody

Popular Products