RegisterLogin

MANF Antibody

CAT: 0223-4349-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4349-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
MANF Antibody: MANF, also known as ARMET, was initially identified as a protein containing an arginine-rich region that was highly mutated in a variety of tumors. More recently it was identified as a mesencephalic astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons, similar to glial cell line-derived neurotrophic factor (GDNF) and CDNF. In rat brain slices, MANF enhanced nigral gamma-aminobutyric acid release. Like GDNF and CDNF, MANF has selective neuroprotective activity for dopaminergic neurons suggesting that it may be indicated for the treatment of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.
NCBI Gene ID
7873
Swiss Prot
P55145
Accession Number
P55145
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
4349
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 2) : Anti-MANF antibodies (4349) detected human MANF recombinant protein at different concentrations. Recombinant Protein Test4349 Induced Expression Validation (Figure 6) : MANF expression detected by anit-MANF antibodies was up-regulated by VPA treatment. Induced Expression Validation
Field of Research
Neuroscience
Purification
MANF Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (92%)
Buffer
MANF Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MANF antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This antibody does not cross-react with CDNF.
Isoform
Human MANF has one isoform (182aa, 21kD) . Mouse MANF has one isoform (179aa, 20kD) and Rat MANF also has one isoform (179aa, 20kD) . 4349 can detect human, mouse and rat.
Symbol
MANF
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Mesencephalic astrocyte derived neurotrophic factor
NCBI Organism
Homo sapiens
Background Reference 01
Shridhar et al. Oncogene 1996; 12:1931-9.
Background Reference 02
Shridhar et al. Cancer Res. 1996; 56:5576-8.
Background Reference 03
Petrova et al. J. Mol. Neurosci. 2003; 20:173-88.
Background Reference 04
Lindholm et al. Nature2007; 448:73-7.
Citation 01
24460582
Citation 02
22243807
Other Product Names
MANF Antibody: ARP, ARMET, ARP, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
23503040
Physical Properties
Liquid

Related Products

CatalogName
4347PMANF Peptide
4349PMANF Peptide
40-563-0025mgMANF Recombinant Protein
91-878MANF Recombinant Protein
40-563-01MANF Recombinant Protein
40-563-0005mgMANF Recombinant Protein
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
25-003L3MBTL2 Antibody

Alternative Products

CatalogName
MBS7128420-01MANF Antibody

Popular Products