MANF Recombinant Protein

CAT: 0223-91-878Size: 0.05 mgDry Ice: NoHazardous: No
CAT#:0223-91-878Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a secreted protein which belongs to the ARMET family. MANF selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. MANF enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. MANF inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF and a homologous protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. MANF expression was widespread in the nervous system and non-neuronal tissues.
CAS Number
9000-83-3
NCBI Gene ID
7873
Swiss Prot
P55145
Accession Number
P55145
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Neuroscience
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
21.5 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Mesencephalic astrocyte derived neurotrophic factor
NCBI Organism
Homo sapiens
Other Product Names
Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET, ARMET, ARP
Species
Human
Physical Properties
Lyophilized

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