MANF Recombinant Protein

CAT: 0223-40-563-01Size: 0.005 mgDry Ice: NoHazardous: No
CAT#:0223-40-563-01Size:0.005 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human MANF is an 18.1 kDa protein consisting of 158 amino acids including 8 cysteine residues.
NCBI Gene ID
7873
Swiss Prot
P55145
Accession Number
NP_006001.3
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Neuroscience
Purity
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized MANF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted MANF stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing MANF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Mesencephalic astrocyte-derived neurotrophic factor
NCBI Organism
Homo sapiens
Other Product Names
ARP, ARMET, ARP, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein
Species
Human
Protein ID
299523086
Physical Properties
Lyophilized

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