ASK1 Antibody

CAT: 0223-3677-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3677-01Size:0.02 mg
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Background
ASK1 Antibody: Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-α -induced apoptosis. ASK1 is expressed in variety of tissues and cell lines.
NCBI Gene ID
4217
Swiss Prot
Q99683
Accession Number
Q99683
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
ASK1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1214 - SW1353 Cell Lysate
Concentration
1 mg/mL
Buffer
ASK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ASK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
MAP3K5
Positive Control 2
Cat. No. 1202 - A431 Cell Lysate
Positive Control 3
Cat. No. 17-002 - A-431 Cell Slide
Positive Control 4
Cat. No. 17-201 - 3T3/BALB Cell Slide
NCBI Official Name
Mitogen-activated protein kinase kinase kinase 5
NCBI Organism
Homo sapiens
Background Reference 01
Ichijo H, Nishida E, Irie K, et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science1997; 275:90-4.
Background Reference 02
Wang XS, Diener K, Jannuzzi D, et al. Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. J. Biol. Chem.1996; 271:31607-11.
Other Product Names
ASK1 Antibody: ASK1, MEKK5, MAPKKK5, ASK1, Mitogen-activated protein kinase kinase kinase 5, Apoptosis signal-regulating kinase 1, ASK-1
Tested Applications
ELISA, WB, ICC, IF
Protein ID
6685617
Physical Properties
Liquid

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