Bcl-B Antibody

• Background:

  Bcl-B Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-B is a recently discovered anti-apoptotic member of the Bcl-2. Unlike the mouse homolog (also known as Diva/Boo) which is predominantly expressed in ovary and testis, the human Bcl-B protein is widely expressed. Also, the human Bcl-B functions by binding to and suppressing the apoptotic activity of Bax, whereas the mouse homolog binds Bak and also interacts with the apoptosis protein Apaf-1.

• NCBI Gene ID:

  10017

• Swiss Prot:

  Q9HD36

• Accession Number:

  NP_065129

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis

• Purification:

  Bcl-B Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  Bcl-B Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Bcl-B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  BCL2L10

• Positive Control 2:

  Cat. No. 17-005 - Jurkat Cell Slide

• NCBI Official Name:

  BCL2-like 10 (apoptosis facilitator)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607

• Background Reference 02:

  Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35.

• Background Reference 03:

  Ke N, Godzik A, and Reed JC. Bcl-B: A novel Bcl-2 family member that differentially binds and regulates Bax and Bak. J. Biol. Chem. 2001; 276:12481-4.

• Background Reference 04:

  Song Q, Kuang Y, Dixit VM, et al. Boo, a negative regulator of cell death, interacts with Apaf-1. EMBO J. 1999; 18:167-78.

• Other Product Names:

  Bcl-B Antibody: Boo, Diva, BCL-B, BCLB, Bcl-2-like protein 10, Anti-apoptotic protein NrH, Bcl2-L-10

• Tested Applications:

  ELISA, WB, ICC

• Protein ID:

  9966783

• Physical Properties:

  Liquid