Bcl-w Antibody

• Background:

  Bcl-w is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.

• NCBI Gene ID:

  599

• Swiss Prot:

  Q92843

• Accession Number:

  Q92843

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Bcl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-59 amino acids from human Bcl.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  21 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BCL2L2

• NCBI Official Name:

  Bcl-2-like protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Denisov, A.Y., et al., J. Biol. Chem. 278 (23) :21124-21128 (2003) .

• Background Reference 02:

  Hinds, M.G., et al., EMBO J. 22 (7) :1497-1507 (2003) .

• Background Reference 03:

  Middleton, G., et al., Development 128 (3) :447-457 (2001) .

• Background Reference 04:

  Ross, A.J., et al., Nat. Genet. 18 (3) :251-256 (1998) .

• Other Product Names:

  Bcl-2-like protein 2, Bcl2-L-2, Apoptosis regulator Bcl-W, BCL2L2, BCLW, KIAA0271

• Tested Applications:

  WB, IHC-P

• Protein ID:

  296434404

• Physical Properties:

  Liquid