DEDD2 Antibody

• Background :

  DEDD2 Antibody: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED) -containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.

• NCBI Gene ID :

  162989

• Swiss Prot :

  Q8WXF8

• Accession Number :

  NP_579874

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Apoptosis

• Purification :

  DEDD2 Antibody is immunoaffinity chromatography purified IgG.

• Positive Control :

  Cat. No. 1283 - RAW 264.7 Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  DEDD2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  DEDD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  DEDD2

• NCBI Official Name :

  Death effector domain containing 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Tibbetts MD, Zheng L, and Lenardo MJ. The death effector domain protein family: regulators of cellular homeostasis. Nat. Immunol. 2003; 4:404-9.

• Background Reference 02 :

  Roth W, Stenner-Liewen F, Pawlowski K, et al. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. 2002; 277:7501-8.

• Background Reference 03 :

  Alcivar A, Hu S, Tang J, et al. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene 2003; 22:291-7.

• Other Product Names :

  DEDD2 Antibody: FLAME-3, FLAME3, PSEC0004, DED-containing protein FLAME-3

• Tested Applications :

  ELISA, WB

• Protein ID :

  19923050

• Physical Properties :

  Liquid