DEDD Antibody

• Background:

  This gene encodes a protein that contains a death effector domain (DED) . DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.

• NCBI Gene ID:

  9191

• Swiss Prot:

  O75618

• Accession Number:

  O75618

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DEDD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-191 amino acids from the Central region of human DEDD.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DEDD

• NCBI Official Name:

  Death effector domain-containing protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Thorenoor, N., et al. Biochemistry 49 (7) :1435-1447 (2010)

• Background Reference 02:

  Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

• Background Reference 03:

  Park, M.Y., et al. Int. J. Cancer 115 (3) :412-418 (2005)

• Background Reference 04:

  Alcivar, A., et al. Oncogene 22 (2) :291-297 (2003)

• Other Product Names:

  Death effector domain-containing protein, DEDPro1, Death effector domain-containing testicular molecule, FLDED-1, DEDD, DEDPRO1, DEFT

• Tested Applications:

  WB

• Physical Properties:

  Liquid