Bcl-10 Antibody

• Background:

  Bcl-10 Antibody: Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-κ B activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.

• NCBI Gene ID:

  8915

• Swiss Prot:

  O95999

• Accession Number:

  AF134395

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer

• Purification:

  Bcl-10 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1207 - Raji Cell Lysate

• Concentration:

  1 mg/ml

• Buffer:

  Bcl-10 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Bcl-10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  31 kDa

• Fragment:

  IgG

• Symbol:

  BCL10

• Positive Control 2:

  Cat. No. 17-007 - Raji Cell Slide

• NCBI Official Name:

  B-cell CLL/lymphoma 10

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Willis TG, Jadayel DM, Du MQ, et al. Bcl10 is involved in t (1;14) (p22; q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 1999;96 (1) :35-45

• Background Reference 02:

  Koseki T, Inohara N, Chen S, et al. CIPER, a novel NF κ B-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10. J Biol Chem 1999;274 (15) :9955-61

• Background Reference 03:

  Yan M, Lee J, Schilbach S, Goddard A, Dixit V. mE10, a novel caspase recruitment domain-containing proapoptotic molecule. J Biol Chem 1999;274 (15) :10287-92

• Background Reference 04:

  Thome M, Martinon F, Hofmann K, et al. Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-κ B transcription factor and c-Jun N-terminal kinase. J Biol Chem 1999;274 (15) :9962-8

• Other Product Names:

  Bcl-10 Antibody: CLAP, mE10, CIPER, c-E10, CARMEN, CLAP, CARD-containing molecule enhancing NF-kappa-B, Bcl-10

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  5070371

• Physical Properties:

  Liquid