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CCG-50014

CAT: 0804-HY-13509-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13509-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].
CAS Number
883050-24-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RGS Protein
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ccg-50014.html
Concentration
10mM
Purity
99.62
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O
Molecular Formula
C16H13FN2O2S
Molecular Weight
316.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Blazer LL, et al. A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. Biochemistry. 2011 Apr 19;50 (15) :3181-92.|[2]Yoon SY, et al. Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test. Anesth Analg. 2015 Mar;120 (3) :671-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RGS16; RGS19; RGS4; RGS8

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