WT1 Rabbit pAb (APR23475N)

CAT: 0882-APR23475N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR23475N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality WT1 Rabbit pAb (APR23475N) .

Synonyms

WT1; AWT1; EWS-WT1; GUD; NPHS4; WAGR; WIT-2; WT33

Gene ID

7490

UniProt

P19544

Cellular Locus

Cytoplasm, Nucleus, Nucleus speckle, nucleolus, nucleoplasm

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 33kDa/34kDa/47kDa/48kDa/49kDa/55kDa/56kDa Observed MW: 60kDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7490

Uniprot URL

https://www.uniprot.org/uniprot/P19544

AA Sequence

Email for sequence

UniProtKB · P19544

Wilms tumor protein

WT1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P19544
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: WT1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A8K6S1, B3KSA5, Q15881, Q16256, Q16575, Q4VXV4, Q4VXV5, Q4VXV6, Q8IYZ5

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative initiationAlternative splicingChromosomal rearrangementRNA editing

Cellular component

CytoplasmNucleus

Disease

Disease variantTumor suppressor

Molecular function

DNA-bindingRNA-binding

PTM

Isopeptide bondUbl conjugation

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

Biological process

TranscriptionTranscription regulation

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