TXNIP (NM_006472) Human Recombinant Protein

• Background:

  This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

• Synonyms:

  ARRDC6; EST01027; HHCPA78; THIF; VDUP1

• Gene ID:

  10628

• UniProt:

  Q9H3M7

• Accession Number mRNA:

  NM_006472

• Chromosomal Location:

  1q21.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  43.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TXNIP

• Species:

  Human

• Protein ID:

  NP_006463

• Overview:

  Recombinant protein of human thioredoxin interacting protein (TXNIP)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10628

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9H3M7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006472

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006463