Txnip (NM_023719) Mouse Recombinant Protein

• Background:

  May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity) . Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  1200008J08Rik; AA682105; Hyplip1; Tbp-2; THIF; VDUP1

• Gene ID:

  56338

• UniProt:

  Q8BG60

• Accession Number mRNA:

  NM_023719

• Chromosomal Location:

  3 41.93 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  44.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Txnip

• Species:

  Mouse

• Protein ID:

  NP_076208

• Overview:

  Purified recombinant protein of Mouse thioredoxin interacting protein (Txnip), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/56338

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8BG60

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_023719

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_076208