ARD-2585

• Description:

  ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor[1].

• UNSPSC:

  12352005

• Target:

  Androgen Receptor; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ard-2585.html

• Purity:

  99.16

• Solubility:

  DMSO : 85 mg/mL (ultrasonic)

• Smiles:

  O=C (N (C1C (NC (CC1) =O) =O) C2=O) C (C2=C3) =CC=C3N (C4) CC4N (CC5) CCN5C (C=C6) =CC=C6C (N[C@@H]7CC[C@@H] (N (C) C8=CC=C (C#N) C (Cl) =C8) CC7) =O

• Molecular Formula:

  C41H43ClN8O5

• Molecular Weight:

  763.28

• References & Citations:

  [1]Weiguo Xiang. et al. Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. J Med Chem. 2021 Sep 23;64 (18) :13487-13509.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2757422-79-8