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Org OD 02-0

CAT: 0804-HY-131547-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131547-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα) -specific agonist (IC50: 33.9 nM) . Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary[1][2].
CAS Number
13258-85-0
Product Name Alternative
10-Ethenyl-19-norprogesterone
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
P38 MAPK; Progesterone Receptor
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/org-od-02-0.html
Purity
99.7
Solubility
DMSO : 24 mg/mL (ultrasonic; warming)
Smiles
CC([C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C=C)[C@@]3([H])CC[C@]12C)=O)=O
Molecular Formula
C22H30O2
Molecular Weight
326.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Kelder J, et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids. 2010 Apr;75 (4-5) :314-22.|[2]Camilletti MA, et al. Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion. J Neuroendocrinol. 2018 Sep;30 (9) :e12614.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

10-Vinyl-19-norpregn-4-ene-3,20-dione
CAS Number13258-85-0
PubChem CID22212907
IUPAC Name(8S,9S,10S,13S,14S,17S)-17-acetyl-10-ethenyl-13-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Molecular FormulaC22H30O2
Molecular Weight326.5
XLogP4.1
Topological Polar Surface Area34.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity630
SMILES
CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C=C)C
InChI
InChI=1S/C22H30O2/c1-4-22-12-9-16(24)13-15(22)5-6-17-19-8-7-18(14(2)23)21(19,3)11-10-20(17)22/h4,13,17-20H,1,5-12H2,2-3H3/t17-,18+,19-,20-,21+,22-/m0/s1
InChIKey
VFNRBPBEOXXVPX-GCOBIYGJSA-N
Chemical Structure
2D Structure
2D structure of 10-Vinyl-19-norpregn-4-ene-3,20-dione
CAS: 13258-85-0
CID: 22212907
Formula: C22H30O2
MW: 326.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight326.5
XLogP34.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass326.224580195
Monoisotopic Mass326.224580195
Topological Polar Surface Area34.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity630
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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