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Org 48762-0

CAT: 0804-HY-114221-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114221-01Size:1 mg
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Description
Org 48762-0 (UR13870) is a potent, orally active and selective p38 inhibitor with an EC50 of 0.1 μM for p38α kinase. Org 48762-0 shows a high degree of kinase selectivity for p38α and p38β over other kinases. Org 48762-0 reduces Lipopolysaccharides (LPS) -induced TNFα release. Org 48762-0 can be used for the study of rheumatoid arthritis (RA) and Werner syndrome[1][2].
CAS Number
755753-89-0
Product Name Alternative
UR13870
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/org-48762-0.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1N=C2C(C(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)C(C5=CC=C(F)C=C5)=N2)=C1
Molecular Formula
C24H16F2N4
Molecular Weight
398.41
References & Citations
[1]K Mihara, et al. A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha. Br J Pharmacol. 2008 May;154 (1) :153-64. |[2]Bagley MC, et al. Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome. Future Med Chem. 2010 Feb;2 (2) :193-201.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α

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