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CXCR2 antagonist 3

CAT: 0804-HY-139874Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139874Size:1 Each
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Description
CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2) . CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1].
CAS Number
2647464-92-2
UNSPSC
12352005
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cxcr2-antagonist-3.html
Solubility
10 mM in DMSO
Smiles
O=S1(C2=C(O)C(NC(NC3=CC=CC(F)=C3C)=O)=CC=C2C=CC1)=O
Molecular Formula
C17H15FN2O4S
Molecular Weight
362.38
References & Citations
[1]Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021;64 (22) :16626-16640.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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