RecQ helicase-IN-1

RecQ helicase-IN-1

• UNSPSC Description: Frangulin B (Compd 11g), a potent anticancer agent, is a potential pan RecQ helicase inhibitor[1]. Frangulin B (Compd 11g) induces apoptosis in both HCT-116 and MDA-MB-231 cell lines, but also causes an G2/M phase cell cycle arrest in HCT-116 cells[1].
• Target Antigen: Apoptosis; DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/recq-helicase-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=CC=CC=C2N=C(/C=C/C3=CC=C(OC)C=C3)N1CC(NC4=CC=CC=C4)=O
• Molecular Weight: 411.45
• References & Citations: [1]Hanan S Haggag, et al. Design and synthesis of quinazolin-4-one derivatives as potential anticancer agents and investigation of their interaction with RecQ helicases. Bioorg Chem. 2024 Jan 4:144:107086.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported