RecQ helicase-IN-1

• UNSPSC Description:

  Frangulin B (Compd 11g), a potent anticancer agent, is a potential pan RecQ helicase inhibitor[1]. Frangulin B (Compd 11g) induces apoptosis in both HCT-116 and MDA-MB-231 cell lines, but also causes an G2/M phase cell cycle arrest in HCT-116 cells[1].

• Target Antigen:

  Apoptosis; DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/recq-helicase-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=CC=CC=C2N=C(/C=C/C3=CC=C(OC)C=C3)N1CC(NC4=CC=CC=C4)=O

• Molecular Weight:

  411.45

• References & Citations:

  [1]Hanan S Haggag, et al. Design and synthesis of quinazolin-4-one derivatives as potential anticancer agents and investigation of their interaction with RecQ helicases. Bioorg Chem. 2024 Jan 4:144:107086.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported